(9R)-9-chloro-11-17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10-13-16-trimethyl-6-7-8-11-12-14-15-16-octahydrocyclopenta[a]phenanthren-3-one and Eye-Diseases

In an open group-comparative study, 123 adult patients with seasonal allergic rhinitis were allocated at random to one of three treatment groups; each of which received a daily dose of 400 micrograms beclomethasone dipropionate as (1) one puff in each nostril four times daily, (2) two puffs in each nostril twice daily and (3) four puffs in each nostril once per day. The result of treatment was assessed on daily symptom scores and the use of antihistamine tablets. There were no statistically significant differences between the three groups. The results indicate that it is unnecessary to give beclomethasone dipropionate nasal spray four times daily, and treatment in the morning and in the evening is recommended.

Topics: Adolescent; Adult; Beclomethasone; Dose-Response Relationship, Drug; Eye Diseases; Female; Humans; Male; Middle Aged; Nasal Mucosa; Pollen; Rhinitis, Allergic, Seasonal

The effect of a daily dose of 400 mug beclomethasone dipropionate aerosol intranasally has been investigated in a double-blind cross-over trial in 29 patients with hay fever. The effect on the nasal symptoms was so pronounced in 25 patients that further symptomatic treatment was unnecessary. Beclomethasone dipropionate aerosol had, on the other hand, no direct effect on itching in the eyes, which is in accordance with the fact that biochemical investigations did not show any sign of suppression of the adrenal function. It is concluded that beclomethasone dipropionate aerosol intranasally is an effective and apparently harmless way of controlling the nasal symptoms in hay fever.

Topics: 17-Ketosteroids; Administration, Intranasal; Adolescent; Adrenal Glands; Adult; Aerosols; Anti-Inflammatory Agents; Beclomethasone; Clinical Trials as Topic; Eye Diseases; Female; Glucocorticoids; Humans; Male; Methylprednisolone; Pruritus; Rhinitis, Allergic, Seasonal

Topics: Adolescent; Asthma; Beclomethasone; Child; Chronic Disease; Dermatitis, Atopic; Eye Diseases; Female; Humans; Male